• You are a healthy male.
• You are at least 18 and at most 55 years old.
• Your weight is at least 50 kg and at most 110 kg and your Body Mass Index (BMI) is at least 18.5 and at most 30 kg/m2 (inclusive). 
• Both non-smokers and light smokers or occasional smokers are allowed to participate in this clinical trial (maximum of 5 cigarettes per day). During your stay in our research facility you are not allowed to smoke.

Note: 

• You cannot participate in the trial if you have participated in another clinical trial in the 30 days prior to the screening of this clinical trial (counting from the follow-up visit). This might be longer for certain trials, please contact us for more information.
• You can only participate in this trial if you have not participated in another trial with a radioactive (14C) labeled compound in the past 12 months. This restriction does not apply for microdose (14C) studies. These studies have a negligible amount of radiation burden, please contact us for more information and to see if this is applicable for you.
• To determine if you are suitable to participate in this trial, you will undergo a medical screening. Depending on availability, this can be performed in Groningen or in Utrecht.

Your female partner is sterilized or has passed the menopause (no periods for at least 12 months);

• You are not sexually active according to your lifestyle;
• You are only sexually active with a partner of the same sex.

The trial consists of 1 period during which you will stay in the research facility in Groningen (location van Swietenlaan 6) for 13 days (12 nights). If not enough radioactivity has left your body after 13 days, there will be one more 24-hour visit. The follow-up visit will take place 7 - 10 days after your last departure from the research facility.

Note: You must be available for all dates to be able to participate in this clinical trial. 

Extra information:

This is a clinical trial with a radioactive (14C) labeled compound. Radioactively labeling a compound is done to be able to study how quickly and to what extent the compound is absorbed, converted and excreted by the body. The radioactivity disappears from the body at the same time as the compound through the feces, urine and/or breath. The compound has a radiation burden which is less than from the natural background radiation that you are exposed to in the Netherlands in 1 month. This background radiation is released from space, soil, air, water, food and construction materials. To measure radioactivity levels in your body, blood, urine and feces will be collected during the trial.