• You are a healthy male or female.
• You are at least 18 and at most 55 years old.
• Your weight is at least 50 kg for males, and 45 kg for females. Your Body Mass Index (BMI) is at least 18.0 and not higher than 30.9 kg/m2. 
• Both non-smokers and light smokers or occasional smokers are allowed to participate in this clinical trial (maximum of 5 cigarettes per day). During your stay in our research facility you are not allowed to smoke.

Note:

• You cannot participate in the trial if you have participated in another clinical trial in 3 months prior to the first compound administration in this clinical trial (counting from the last dosing of the previous trial).
• To determine if you are suitable to participate in this trial, you will undergo a medical screening. Depending on availability, this can be performed in Groningen or in Utrecht.

As a female you can only participate if you are not pregnant, not breast feeding and meet one of the following conditions:

• You have passed the menopause (no periods for at least 12 months);
• You have been sterilized.

As a male you can only participate if you meet one of the following conditions:

• You are using a condom in combination with an additional contraception method used by your female partner;
• You have been sterilized or your female partner is sterilized or has passed the menopause (no periods for at least 12 months);
• You are not sexually active according to your lifestyle;
• You are only sexually active with a partner of the same sex.

Part 4: The trial consists of 1 period during which you will stay in the research facility in Groningen (location van Swietenlaan 6) for 24 days (23 nights). The follow-up visit will take place 2 to 8 days after your departure from the research facility.

Note: You must be available for all dates to be able to participate in this clinical trial.