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Obesity

RO0165-1338-GRQ

  • M/F
  • 18 - 65 years old
  • Healthy

Clinical trial of a new compound that is being developed for the treatment of obesity.

  • From July 2026
  • 39 days
    (Spread over several periods)
  • 20 visits

€16.491,-

Register without obligation

It was a fantastic experience with friendly staff.

Rupert Participant ICON

Find out if you qualify for this trial

  • You are a healthy male or female
  • You are between 18 and 65 years old
  • You weigh more than 60 kg
  • Your Body Mass Index (BMI) is between 25 and 35 kg/m2

Good to know about this trial

  • All periods and short visits will take place in Groningen
  • For this clinical trial we are looking for particpants with a BMI between 25.0 - 35.0 kg/m2 
  • The study compound has been administered to overweight and obese, otherwise healthy, people.

 

 

It was a fantastic experience with friendly staff.

Rupert Participant ICON

How does it work

How does it work?

Read more

  1. 1

    Registering

    Register for the trial and the group you choose. After your registration, call ICON to discuss the study and make an appointment for your medical examination.

  2. 2

    Medical screening

    If you meet the requirements of the trial, then a medical screening takes place at our screening center in Groningen or Utrecht.

  3. 3

    The trial

    The clinical trial is conducted at ICON's research center in Groningen. There you will eat, sleep and stay during the trial.

  4. 4

    Follow-up & Compensation

    A follow-up screening always takes place after the trial. You will receive the compensation for your participation, within 30 days.

Read more

Study groups

Register without obligation for the group of your preference

  • Group 2

    • 13 up to and including 25 July
    • 8 up to and including 10 September
    • 6 up to and including 7 October
    • 3 up to and including 5 November
    • 22 up to and including 24 December
    • 28 up to and including 31 December
    • 5 up to and including 12 January
    • 26 up to and including 28 January

    Period(s) of stay
    1 x 13 days, 4 x 3 days, 1 x 2 days, 1 x 4 days, 1 x 8 days

    • 13 up to and including 25 July
    • 8 up to and including 10 September
    • 6 up to and including 7 October
    • 3 up to and including 5 November
    • 22 up to and including 24 December
    • 28 up to and including 31 December
    • 5 up to and including 12 January
    • 26 up to and including 28 January

    • 28 July
    • 4 August
    • 11 August
    • 18 August
    • 25 August
    • 1 September
    • 15 September
    • 22 September
    • 29 September
    • 13 October
    • 20 October
    • 27 October
    • 10 November
    • 17 November
    • 24 November
    • 1 December
    • 8 December
    • 15 December
    • 19 January

    Visit(s) (19 days)

    • 28 July
    • 4 August
    • 11 August
    • 18 August
    • 25 August
    • 1 September
    • 15 September
    • 22 September
    • 29 September
    • 13 October
    • 20 October
    • 27 October
    • 10 November
    • 17 November
    • 24 November
    • 1 December
    • 8 December
    • 15 December
    • 19 January

    • 23 February (physically)

    Follow-up(s) (1 day)

    • 23 February (physically)

    • €16.491,-

    Compensation

    • €16.491,-

    The entire trial will take place in Groningen. Visits in Utrecht are not possible.

    Groningen

    The entire trial will take place in Groningen. Visits in Utrecht are not possible.

    Register

  • Group 3 - only females!

    • 11 up to and including 23 August
    • 7 up to and including 9 October
    • 4 up to and including 5 November
    • 2 up to and including 4 December
    • 20 up to and including 22 January
    • 27 up to and including 30 January
    • 3 up to and including 10 February
    • 24 up to and including 26 February

    Period(s) of stay
    1 x 13 days, 4 x 3 days, 1 x 2 days, 1 x 4 days, 1 x 8 days

    • 11 up to and including 23 August
    • 7 up to and including 9 October
    • 4 up to and including 5 November
    • 2 up to and including 4 December
    • 20 up to and including 22 January
    • 27 up to and including 30 January
    • 3 up to and including 10 February
    • 24 up to and including 26 February

    • 26 August
    • 2 September
    • 9 September
    • 16 September
    • 23 September
    • 30 September
    • 14 October
    • 21 October
    • 28 October
    • 11 November
    • 18 November
    • 25 November
    • 9 December
    • 16 December
    • 23 December
    • 30 December
    • 6 January
    • 13 January
    • 17 February

    Visit(s) (19 days)

    • 26 August
    • 2 September
    • 9 September
    • 16 September
    • 23 September
    • 30 September
    • 14 October
    • 21 October
    • 28 October
    • 11 November
    • 18 November
    • 25 November
    • 9 December
    • 16 December
    • 23 December
    • 30 December
    • 6 January
    • 13 January
    • 17 February

    • 24 March (physically)

    Follow-up(s) (1 day)

    • 24 March (physically)

    • €16.491,-

    Compensation

    • €16.491,-

    The entire trial will take place in Groningen. Visits in Utrecht are not possible.

    Groningen

    The entire trial will take place in Groningen. Visits in Utrecht are not possible.

    Register

  • Group 1

    • 14 up to and including 26 June
    • 10 up to and including 12 August
    • 7 up to and including 8 September
    • 5 up to and including 7 October
    • 23 up to and including 25 November
    • 30 November up to and including 3 December
    • 7 up to and including 14 December
    • 28 up to and including 30 December

    Period(s) of stay
    1 x 13 days, 4 x 3 days, 1 x 2 days, 1 x 4 days, 1 x 8 days

    • 14 up to and including 26 June
    • 10 up to and including 12 August
    • 7 up to and including 8 September
    • 5 up to and including 7 October
    • 23 up to and including 25 November
    • 30 November up to and including 3 December
    • 7 up to and including 14 December
    • 28 up to and including 30 December

    • 29 June
    • 6 July
    • 13 July
    • 20 July
    • 27 July
    • 3 August
    • 17 August
    • 24 August
    • 31 August
    • 14 September
    • 21 September
    • 28 September
    • 12 October
    • 19 October
    • 26 October
    • 2 November
    • 9 November
    • 16 November
    • 21 December

    Visit(s) (19 days)

    • 29 June
    • 6 July
    • 13 July
    • 20 July
    • 27 July
    • 3 August
    • 17 August
    • 24 August
    • 31 August
    • 14 September
    • 21 September
    • 28 September
    • 12 October
    • 19 October
    • 26 October
    • 2 November
    • 9 November
    • 16 November
    • 21 December

    • 25 January (physically)

    Follow-up(s) (1 day)

    • 25 January (physically)

    • €16.491,-

    Compensation

    • €16.491,-

    The entire trial will take place in Groningen. Visits in Utrecht are not possible.

    Groningen

    The entire trial will take place in Groningen. Visits in Utrecht are not possible.

    Full

  • Group 4

    • 9 up to and including 21 September
    • 5 up to and including 7 November
    • 3 up to and including 4 December
    • 29 up to and including 31 December
    • 18 up to and including 20 February
    • 25 up to and including 28 February
    • 4 up to and including 11 March
    • 25 up to and including 27 March

    Period(s) of stay
    1 x 13 days, 4 x 3 days, 1 x 2 days, 1 x 4 days, 1 x 8 days

    • 9 up to and including 21 September
    • 5 up to and including 7 November
    • 3 up to and including 4 December
    • 29 up to and including 31 December
    • 18 up to and including 20 February
    • 25 up to and including 28 February
    • 4 up to and including 11 March
    • 25 up to and including 27 March

    • 24 September
    • 1 October
    • 8 October
    • 15 October
    • 22 October
    • 29 October
    • 12 November
    • 19 November
    • 26 November
    • 10 December
    • 17 December
    • 24 December
    • 7 January
    • 14 January
    • 21 January
    • 28 January
    • 4 February
    • 11 February
    • 18 March

    Visit(s) (19 days)

    • 24 September
    • 1 October
    • 8 October
    • 15 October
    • 22 October
    • 29 October
    • 12 November
    • 19 November
    • 26 November
    • 10 December
    • 17 December
    • 24 December
    • 7 January
    • 14 January
    • 21 January
    • 28 January
    • 4 February
    • 11 February
    • 18 March

    • 22 April (physically)

    Follow-up(s) (1 day)

    • 22 April (physically)

    • €16.491,-

    Compensation

    • €16.491,-

    The entire trial will take place in Groningen. Visits in Utrecht are not possible.

    Groningen

    The entire trial will take place in Groningen. Visits in Utrecht are not possible.

    Full

The research physician about this research

Additional information

In this clinical trial we will investigate how safe the study compound is and how well it is tolerated. The study compound is given either alone or in combination with the birth control pill or paracetamol. We will also compare the blood concentrations of the pill and paracetamol when they are given without the study compound to when they are given together with the study compound. The pill and paracetamol are approved compounds that are available in the Netherlands. The doses of the pill and paracetamol that are used in this clinical trial are safe and well tolerated.

We will also investigate how the study compound affects stomach emptying. Stomach emptying means how food moves from the stomach to the small intestine. Similar compounds are known to slow this movement. When food moves more slowly through the stomach, the absorption of compounds taken by mouth may be delayed. This can affect how they work. To understand how the study compound affects stomach emptying, we will use paracetamol. Paracetamol is not absorbed in the stomach, but it is absorbed quickly in the small intestine. This makes it useful for measuring how fast the stomach empties. We will also check whether the study compound affects how the pill is absorbed. If stomach emptying is delayed, the way the pill is absorbed may change.

We will compare the effects of the study compound with the effects of a placebo. A placebo is a compound without any active ingredient. Whether you will receive the study compound or placebo will be determined by chance.

You will be given the study compound or placebo as an injection under the skin. On the day of the study compound or placebo administration, you will receive a light breakfast. After the light breakfast, you will take the pill by mouth with water. Paracetamol is dissolved and mixed with a liquid meal.

Although the study compound is still early in development, it has been administered to overweight and obese, but otherwise healthy, people. Participants reported gastrointestinal-related side-effects, most commonly decreased appetite. In general, these side effects were mild. You may also experience other, yet unknown, side effects. Prior to the medical screening, you will receive written information about the trial, which also describes the possible side effects. This information will also be discussed with you at the start of the medical screening. You can then ask questions to the screening physician or nurse. Once everything is clear to you, you can decide to give written consent to participate in the trial. The medical screening will only take place after you have given written consent to participate in the trial. We want to emphasize that even after giving written consent, participation in any clinical trial is voluntary. You can decide at any time not to participate or to stop the medical screening or the trial. You do not need to provide a reason for why you no longer wish to participate.

Who can participate?

Target group

  • You are a healthy male or female.
  • You are at least 18 and at most 65 years old.
  • Your weight is at least 60 kg and your Body Mass Index (BMI) is at least 25.0 and at most 35.0 kg/m2. The BMI shows the relationship between body weight in kilograms and height in meters.
  • Both non-smokers and light smokers or occasional smokers (max. 5 cigarettes per day) are eligible to participate in this clinical trial. During your stay in our research facility you are not allowed to smoke.
  • As a female you can only participate if you are not pregnant, not breast feeding and meet one of the following conditions:
    • You use hormonal contraception in combination with a condom (Please note that most contraceptive pills and all intrauterine devices containing hormones are not allowed. A progestogen-only pill, implant or injection is allowed. Please contact us for more information);
    • You use a copper intra-uterine device in combination with a condom;
    • You have passed the menopause (no periods for at least 12 months);
    • You have been sterilized or your male partner has been sterilized;
    • You are only sexually active with a partner of the same sex;
    • You are not sexually active according to your lifestyle.
  • For males, there are no requirements regarding contraception.

Note: 

  • You cannot participate in the trial if you have participated in another clinical trial in the 90 days prior to the day of admission into this clinical trial (counting from the follow-up visit of the previous trial). This may be longer in certain trials, so please contact us for more information.
  • To determine if you are suitable to participate in this trial, you will undergo a medical screening. Depending on availability, this can be performed in Groningen or in Utrecht.

What is the compensation for this research?

Compensation

You will receive a gross compensation of € 16.491,- for full participation in this trial.

Travel expenses will be reimbursed based on the distance traveled (€ 0.23 per kilometer) with a minimum of € 14.23 and a maximum of € 193.20 (840 kilometers) per round trip, regardless of the mode of transportation.

How long does this research take?

Period of stay and research

The trial consists of multiple periods ranging from 2 days (1 night) up to 13 days (12 nights) in which you will stay in the research facility in Groningen. In total, there are 20 shorts visits, including the follow-up visit.

Note: You must be available for all dates to be able to participate in this clinical trial. Please note that all periods and shorts visits will take place in Groningen. The location in Groningen is Van Swietenlaan 6.

Frequently asked questions

If you are participating in a trial for which you have to stay at the research center for longer than ten days, it is sometimes possible to have visitors (in consultation).

During the trial, you may suffer from mild symptoms like headache or nausea. That may be caused by the medication. It might also be caused by needing to fast for the trial, for example. Those side effects are no fun, but fortunately are not dangerous.

Before a medication is tested on people, it has already been studied extensively in a lab. This enables us to predict well which side effects you might get and we can prepare you for them. It almost never happens that participants suffer from unexpected side effects. For example, an allergic reaction to the medication occurs on average once a year.

The amount of money you receive for your participation in a clinical trial is determined by the duration of the trial. The longer the trial takes, the higher the compensation. But there are also other factors that determine the amount of the compensation awarded, such as special medical procedures.

You can participate in a trial a maximum of four times a year. There must be at least 30 days between two trials. Some trials have a longer waiting period.

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